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Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1.
Qi, Junpeng; Li, Xiuling; Peng, Haiyong; Cook, Erika M; Dadashian, Eman L; Wiestner, Adrian; Park, HaJeung; Rader, Christoph.
Affiliation
  • Qi J; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458.
  • Li X; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458.
  • Peng H; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458.
  • Cook EM; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
  • Dadashian EL; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
  • Wiestner A; Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
  • Park H; X-Ray Crystallography Core, The Scripps Research Institute, Jupiter, FL 33458.
  • Rader C; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL 33458; crader@scripps.edu.
Proc Natl Acad Sci U S A ; 115(24): E5467-E5476, 2018 06 12.
Article in En | MEDLINE | ID: mdl-29844189
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Antibodies, Bispecific / Receptor Tyrosine Kinase-like Orphan Receptors / Epitopes / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Antibodies, Bispecific / Receptor Tyrosine Kinase-like Orphan Receptors / Epitopes / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Document type: Article Country of publication: United States