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"Biomimetic-electrochemical-sensory-platform" for biomolecule free cocaine testing.
Yilmaz Sengel, Tulay; Guler, Emine; Arslan, Mustafa; Gumus, Z Pinar; Sanli, Serdar; Aldemir, Ebru; Akbulut, Huseyin; Odaci Demirkol, Dilek; Coskunol, Hakan; Timur, Suna; Yagci, Yusuf.
Affiliation
  • Yilmaz Sengel T; Ege University, Faculty of Science, Biochemistry Department, 35100 Bornova, Izmir, Turkey.
  • Guler E; Ege University, Faculty of Science, Biochemistry Department, 35100 Bornova, Izmir, Turkey.
  • Arslan M; Istanbul Technical University, Department of Chemistry, Faculty of Science and Letters, Istanbul, Turkey.
  • Gumus ZP; Institute of Drug Abuse Toxicology & Pharmaceutical Sciences, Ege University, 35100-Bornova, Izmir, Turkey; Central Research Testing and Analysis Laboratory Research and Application Center, Ege University, Bornova, Izmir, Turkey.
  • Sanli S; Ege University, Faculty of Science, Biochemistry Department, 35100 Bornova, Izmir, Turkey.
  • Aldemir E; Institute of Drug Abuse Toxicology & Pharmaceutical Sciences, Ege University, 35100-Bornova, Izmir, Turkey.
  • Akbulut H; Istanbul Technical University, Department of Chemistry, Faculty of Science and Letters, Istanbul, Turkey.
  • Odaci Demirkol D; Ege University, Faculty of Science, Biochemistry Department, 35100 Bornova, Izmir, Turkey.
  • Coskunol H; Ege University, Faculty of Medicine, Addiction Treatment Center, 35100, Bornova, Izmir, Turkey.
  • Timur S; Ege University, Faculty of Science, Biochemistry Department, 35100 Bornova, Izmir, Turkey; Central Research Testing and Analysis Laboratory Research and Application Center, Ege University, Bornova, Izmir, Turkey. Electronic address: suna.timur@ege.edu.tr.
  • Yagci Y; Istanbul Technical University, Department of Chemistry, Faculty of Science and Letters, Istanbul, Turkey; King Abdulaziz University, Faculty of Science, Chemistry Department, Jeddah, Saudi Arabia. Electronic address: yusuf@itu.edu.tr.
Mater Sci Eng C Mater Biol Appl ; 90: 211-218, 2018 Sep 01.
Article in En | MEDLINE | ID: mdl-29853084
ABSTRACT
A biomimetic cocaine sensor was fabricated by using poly(p-phenylene) (PPP) with cyclodextrin (CD) units in the backbone and poly(ethylene glycol) (PEG) side chains (PPP-CD-g-PEG). The sensory platform was constructed by one step surface modification of glassy carbon electrode with PPP-CD-g-PEG by drop coating. The electrochemical measurements are based on the formation of CD-cocaine inclusion complex on the surface resulting in a significant decrease in electron transfer capacity of the selected redox probe. The changes in the surface features due to cocaine binding were explored via electrochemical techniques such as differential pulse voltammetry, cyclic voltammetry and electrochemical impedance spectrometry. The sensor exhibited linearity in the range of 25-200 nM cocaine, LOD was calculated as 28.62 nM (n = 5) according to 3Sb/m formula. Finally, the sensory platform was successfully applied for the cocaine analysis in synthetic urine samples and correlated with the chromatographic method.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cocaine / Nanotubes, Carbon Language: En Journal: Mater Sci Eng C Mater Biol Appl Year: 2018 Document type: Article Affiliation country: Turkey
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cocaine / Nanotubes, Carbon Language: En Journal: Mater Sci Eng C Mater Biol Appl Year: 2018 Document type: Article Affiliation country: Turkey