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Rapid Bioavailability and Disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state brain distribution with reduced animal usage.
Fu, Tingting; Gao, Ruina; Scott-Stevens, Paul; Chen, Yan; Zhang, Chalmers; Wang, Jianfei; Summerfield, Scott; Liu, Houfu; Sahi, Jasminder.
Affiliation
  • Fu T; Platform Technology and Science, GlaxoSmithKline R&D Shanghai, China. Electronic address: tingting.t.fu@gsk.com.
  • Gao R; Platform Technology and Science, GlaxoSmithKline R&D Shanghai, China.
  • Scott-Stevens P; Platform Technology and Science, GlaxoSmithKline R&D Ware, UK.
  • Chen Y; Platform Technology and Science, GlaxoSmithKline R&D Shanghai, China.
  • Zhang C; Platform Technology and Science, GlaxoSmithKline R&D Shanghai, China.
  • Wang J; Platform Technology and Science, GlaxoSmithKline R&D Shanghai, China.
  • Summerfield S; Platform Technology and Science, GlaxoSmithKline R&D Ware, UK.
  • Liu H; Platform Technology and Science, GlaxoSmithKline R&D Shanghai, China.
  • Sahi J; Platform Technology and Science, GlaxoSmithKline R&D Shanghai, China.
Eur J Pharm Sci ; 122: 13-21, 2018 Sep 15.
Article in En | MEDLINE | ID: mdl-29857045
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Pharmacokinetics / High-Throughput Screening Assays / Models, Biological Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2018 Document type: Article Country of publication: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Pharmacokinetics / High-Throughput Screening Assays / Models, Biological Type of study: Prognostic_studies Limits: Animals Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2018 Document type: Article Country of publication: Netherlands