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Targeting the TGFß pathway with galunisertib, a TGFßRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade.
Holmgaard, Rikke B; Schaer, David A; Li, Yanxia; Castaneda, Stephen P; Murphy, Mary Y; Xu, Xiaohong; Inigo, Ivan; Dobkin, Julie; Manro, Jason R; Iversen, Philip W; Surguladze, David; Hall, Gerald E; Novosiadly, Ruslan D; Benhadji, Karim A; Plowman, Gregory D; Kalos, Michael; Driscoll, Kyla E.
Affiliation
  • Holmgaard RB; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Schaer DA; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Li Y; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Castaneda SP; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Murphy MY; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Xu X; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Inigo I; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Dobkin J; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Manro JR; 0000 0000 2220 2544grid.417540.3Lilly Research Laboratories, Eli Lilly and Company 46285 Indianapolis IN USA.
  • Iversen PW; 0000 0000 2220 2544grid.417540.3Lilly Research Laboratories, Eli Lilly and Company 46285 Indianapolis IN USA.
  • Surguladze D; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Hall GE; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Novosiadly RD; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Benhadji KA; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Plowman GD; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Kalos M; 0000 0000 2220 2544grid.417540.3Eli Lilly and Company 450 East 29th Street New York USA.
  • Driscoll KE; Janssen Pharmaceutical Companies of Johnson and Johnson Spring House PA USA.
J Immunother Cancer ; 6(1): 47, 2018 06 04.
Article in En | MEDLINE | ID: mdl-29866156
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Quinolines / Transforming Growth Factor beta / Combined Modality Therapy / Immunotherapy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Immunother Cancer Year: 2018 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Quinolines / Transforming Growth Factor beta / Combined Modality Therapy / Immunotherapy Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Immunother Cancer Year: 2018 Document type: Article Country of publication: United kingdom