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Nanoformulated paclitaxel and AZD9291 synergistically eradicate non-small-cell lung cancers in vivo.
Wang, Xin-Shuai; Zhang, Li; Li, Xiaocen; Kong, De-Jiu; Hu, Xiao-Chen; Ding, Xue-Zhen; Yang, Jun-Qiang; Zhao, Meng-Qi; He, Yixuan; Lam, Kit S; Gao, She-Gan; Lin, Tzu-Yin; Li, Yuanpei.
Affiliation
  • Wang XS; Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan, University of Science & Technology, Luoyang 471003, China.
  • Zhang L; Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan, University of Science & Technology, Luoyang 471003, China.
  • Li X; Department of Biochemistry & Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA.
  • Kong DJ; Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan, University of Science & Technology, Luoyang 471003, China.
  • Hu XC; Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan, University of Science & Technology, Luoyang 471003, China.
  • Ding XZ; Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan, University of Science & Technology, Luoyang 471003, China.
  • Yang JQ; Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan, University of Science & Technology, Luoyang 471003, China.
  • Zhao MQ; Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan, University of Science & Technology, Luoyang 471003, China.
  • He Y; Department of Biochemistry & Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA.
  • Lam KS; Department of Biochemistry & Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA.
  • Gao SG; Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan, University of Science & Technology, Luoyang 471003, China.
  • Lin TY; Department of Internal Medicine, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
  • Li Y; Department of Biochemistry & Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA.
Nanomedicine (Lond) ; 13(10): 1107-1120, 2018 05.
Article in En | MEDLINE | ID: mdl-29874151
ABSTRACT

AIM:

This study aims to develop new nanoformulations of EGFR T790M targeted inhibitor AZD9291 and paclitaxel (PTX) for combination therapy of lung cancer. MATERIALS &

METHODS:

We prepared and characterized PTX- and AZD9291-loaded disulfide cross-linking micelles (DCMs), and evaluate their combination effect and toxicity in vitro and in lung cancer-bearing mice.

RESULTS:

Drug-loaded DCMs were relatively small in size, and possessed glutathione-responsive drug release. The combination of PTX-DCMs and AZD92921-DCMs exhibited strong synergistic effects in both cell line and in vivo without additional toxicity. Molecular studies demonstrated the synergistic modification in both IKB-α/NF-κB/Bcl-2 and EGFR/Akt pathways.

CONCLUSION:

The combination of DCM-loaded AZD9291 and PTX could potentially offer more effective and less toxicity treatment options for lung cancer patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acrylamides / Drug Delivery Systems / Paclitaxel / Carcinoma, Non-Small-Cell Lung / Aniline Compounds Limits: Animals / Humans Language: En Journal: Nanomedicine (Lond) Year: 2018 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acrylamides / Drug Delivery Systems / Paclitaxel / Carcinoma, Non-Small-Cell Lung / Aniline Compounds Limits: Animals / Humans Language: En Journal: Nanomedicine (Lond) Year: 2018 Document type: Article Affiliation country: China