The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease.

Simons, K H; de Vries, M R; Peters, H A B; Hamming, J F; Jukema, J W; Quax, P H A

Simons, K H; de Vries, M R; Peters, H A B; Hamming, J F; Jukema, J W; Quax, P H A.

Affiliation

Simons KH; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: k.h.simons@lumc.nl.
de Vries MR; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Peters HAB; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Hamming JF; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Jukema JW; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Quax PHA; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.

J Mol Cell Cardiol ; 121: 16-24, 2018 08.

Article in En | MEDLINE | ID: mdl-29879406

Subject(s)

Carrier Proteins/genetics; Toll-Like Receptor 3/genetics; Transplants/metabolism; Veins/growth & development; Adaptor Proteins, Signal Transducing; Animals; Bone Marrow Cells/metabolism; Bone Marrow Cells/pathology; Carotid Arteries/growth & development; Carotid Arteries/metabolism; Cell Differentiation/genetics; Endothelial Cells/metabolism; Endothelial Cells/pathology; Gene Expression Regulation/genetics; Humans; Interferon Type I/genetics; Ligands; Macrophages/metabolism; Mice; Myocytes, Smooth Muscle/metabolism; Myocytes, Smooth Muscle/pathology; RNA-Binding Proteins; Signal Transduction/genetics; Toll-Like Receptor 2/genetics; Toll-Like Receptor 4/genetics; Transplants/growth & development; Transplants/pathology; Veins/metabolism

Key words

Toll like receptor; Type I interferon; Vascular remodeling; Vein graft disease

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Veins / Carrier Proteins / Transplants / Toll-Like Receptor 3 Limits: Animals / Humans Language: En Journal: J Mol Cell Cardiol Year: 2018 Document type: Article Country of publication: United kingdom

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