Your browser doesn't support javascript.
loading
Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models.
Gandhi, Gopalsamy Rajiv; Neta, Maria Terezinha Santos Leite; Sathiyabama, Rajiv Gandhi; Quintans, Jullyana de Souza Siqueira; de Oliveira E Silva, Ana Mara; Araújo, Adriano Antunes de Souza; Narain, Narendra; Júnior, Lucindo José Quintans; Gurgel, Ricardo Queiroz.
Affiliation
  • Gandhi GR; Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Cláudio Batista, s/n, Cidade Nova, Aracaju 49.100-000 Sergipe, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, 49.100-000
  • Neta MTSL; Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil.
  • Sathiyabama RG; Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Cláudio Batista, s/n, Cidade Nova, Aracaju 49.100-000 Sergipe, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, 49.100-000
  • Quintans JSS; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil.
  • de Oliveira E Silva AM; Department of Nutrition, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil.
  • Araújo AAS; Department of Pharmacy, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil.
  • Narain N; Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil.
  • Júnior LJQ; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, São Cristóvão, 49.100-000 Sergipe, Brazil.
  • Gurgel RQ; Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Cláudio Batista, s/n, Cidade Nova, Aracaju 49.100-000 Sergipe, Brazil.
Phytomedicine ; 44: 74-84, 2018 May 15.
Article in En | MEDLINE | ID: mdl-29895495
ABSTRACT

BACKGROUND:

Flavonoids are naturally occurring compounds, extensively distributed in plants. T helper (Th)1 and Th2 cytokines balance plays an essential role in the reaction of inflammatory, allergic and infectious processes and transplantation rejection.

PURPOSE:

This systematic review focuses on various classes of flavonoids with a view to evaluate whether Th1/Th2 cytokine-mediated pathways of immunoenhancement could reduce immune overwhelming reactions.

METHODS:

Articles in English published from inception to December 2017 reporting flavonoids with immunomodulatory activity for the management of immune-mediated disorders were acquired from PubMed, EMBASE, Scopus and Web of Science and a animal experiments where Th1 and Th2 cytokines were investigated to assess the outcome of immunoregulatory therapy were included. CHAPTERS 1809 publications were identified and 26 were included in this review. Ten articles described the effect of flavonoids on allergic inflammation in an animal model of asthma; eleven in vivo studies evaluated the immunomodulating and immunosuppressive effects of flavonoids on Th1/Th2 cytokines production and five reports described the regulatory role of flavonoids for Th1/Th2 cytokine responses to experimental arthritis and myocarditis. Modulation of Th1/Th2 cytokine balance, inhibition of eosinophil accumulation and remodeling of the airways and lungs, downregulation of Notch and PI3K signaling pathways, regulation of CD4 + /CD8 + lymphocytes ratio and decreasing inflammatory mediator expressions levels are among the most important immunopharmacological mechanisms for the retrieved flavonoids.

CONCLUSION:

Naturally occurring flavonoids discussed in the present article have optimal immunomodulation to prevent immune-mediated disorders through management of Th1/Th2 cytokine balance.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Th2 Cells / Th1 Cells / Immunologic Factors Type of study: Prognostic_studies / Systematic_reviews Limits: Animals Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2018 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Th2 Cells / Th1 Cells / Immunologic Factors Type of study: Prognostic_studies / Systematic_reviews Limits: Animals Language: En Journal: Phytomedicine Journal subject: TERAPIAS COMPLEMENTARES Year: 2018 Document type: Article