Orally administered adenoviral-based vaccine induces respiratory mucosal memory and protection against RSV infection in cotton rats.
Vaccine
; 36(29): 4265-4277, 2018 07 05.
Article
in En
| MEDLINE
| ID: mdl-29895499
ABSTRACT
A vaccine against Respiratory Syncytial Virus (RSV) is a major unmet need to prevent the significant morbidity and mortality that it causes in society. In addition to efficacy, such a vaccine must not induce adverse events, as previously occurred with a formalin-inactivated vaccine (FI-RSV). In this study, the safety, immunogenicity and efficacy of a molecularly adjuvanted adenovirus serotype 5 based RSV vaccine encoding the fusion (F) protein (Ad-RSVF) is demonstrated in cotton rats. Protective immunity to RSV was induced by Ad-RSVF when administered by an oral route as well as by intranasal and intramuscular routes. Compared to FI-RSV, the Ad-RSVF vaccine induced significantly greater neutralizing antibody responses and protection against RSV infection. Significantly, oral or intranasal immunization each induced protective multi-functional effector and memory B cell responses in the respiratory tract. This study uniquely demonstrates the capacity of an orally administered adenovirus vaccine to induce protective immunity in the respiratory tract against RSV in a pre-clinical model and supports further clinical development of this oral Ad-RSVF vaccine strategy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Syncytial Viruses
/
Drug Carriers
/
Adenoviridae
/
Viral Fusion Proteins
/
Respiratory Syncytial Virus Infections
/
Respiratory Syncytial Virus Vaccines
Limits:
Animals
Language:
En
Journal:
Vaccine
Year:
2018
Document type:
Article
Affiliation country:
United States