Your browser doesn't support javascript.
loading
BLT2, a leukotriene B4 receptor 2, as a novel prognostic biomarker of triple-negative breast cancer.
Park, JaeIn; Jang, Jae-Hyun; Park, Geun-Soo; Chung, Yunro; You, Hye Jin; Kim, Jae-Hong.
Affiliation
  • Park J; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
  • Jang JH; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
  • Park GS; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
  • Chung Y; Department of Biomedical Informatics, Arizona State University, Scottsdale, AZ 85259, USA.
  • You HJ; Translational Research Branch, Division of Translational Science, National Cancer Center, Goyang 10408, Korea.
  • Kim JH; Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
BMB Rep ; 51(8): 373-377, 2018 Aug.
Article in En | MEDLINE | ID: mdl-29898809
ABSTRACT
Triple-negative breast cancer (TNBC) is considered to be a notorious type of cancer due to its aggressive metastatic potential and poor prognosis. Recent evidence suggests that BLT2, a low-affinity LTB4 receptor is critically associated with the phenotypes of TNBC cells, including invasion, metastasis, and survival. Furthermore, in a group of 545 breast cancer patients with metastasis, we observed that the high-BLT2 subgroup had a lower disease-free-survival rate than the low-BLT2 subgroup. Thus, we theorized that anti-BLT2 strategies could facilitate the development of new therapies used for TNBC. This review focuses on recent discoveries regarding BLT2 and its roles in as a novel prognostic biomarker in TNBC. [BMB Reports 2018; 51(8) 373-377].
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Leukotriene B4 / Triple Negative Breast Neoplasms Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: BMB Rep Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2018 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Leukotriene B4 / Triple Negative Breast Neoplasms Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: BMB Rep Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2018 Document type: Article