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NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.
Samokhin, Andriy O; Stephens, Thomas; Wertheim, Bradley M; Wang, Rui-Sheng; Vargas, Sara O; Yung, Lai-Ming; Cao, Minwei; Brown, Marcel; Arons, Elena; Dieffenbach, Paul B; Fewell, Jason G; Matar, Majed; Bowman, Frederick P; Haley, Kathleen J; Alba, George A; Marino, Stefano M; Kumar, Rahul; Rosas, Ivan O; Waxman, Aaron B; Oldham, William M; Khanna, Dinesh; Graham, Brian B; Seo, Sachiko; Gladyshev, Vadim N; Yu, Paul B; Fredenburgh, Laura E; Loscalzo, Joseph; Leopold, Jane A; Maron, Bradley A.
Affiliation
  • Samokhin AO; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Stephens T; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Wertheim BM; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Wang RS; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Vargas SO; Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Yung LM; Department of Pathology, Boston Children's Hospital, Boston, MA 02115, USA.
  • Cao M; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Brown M; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Arons E; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Dieffenbach PB; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Fewell JG; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Matar M; Celsion Corporation, Lawrenceville, NJ 08648, USA.
  • Bowman FP; Celsion Corporation, Lawrenceville, NJ 08648, USA.
  • Haley KJ; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Alba GA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Marino SM; Department of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Kumar R; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Rosas IO; Department of Biotechnology, Akdeniz University, Konyaalti, Antalya 07058, Turkey.
  • Waxman AB; Program in Translational Lung Research, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Oldham WM; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Khanna D; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Graham BB; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Seo S; Division of Rheumatology, University of Michigan Scleroderma Program, Ann Arbor, MI 48109, USA.
  • Gladyshev VN; Program in Translational Lung Research, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
  • Yu PB; Department of Hematology and Oncology, National Cancer Research Center East, Kashiwa-shi, Chiba-ken 277-8577, Japan.
  • Fredenburgh LE; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Loscalzo J; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Leopold JA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Maron BA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Sci Transl Med ; 10(445)2018 06 13.
Article in En | MEDLINE | ID: mdl-29899023
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Fibrosis / Collagen Type III / Adaptor Proteins, Signal Transducing / Lung Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Fibrosis / Collagen Type III / Adaptor Proteins, Signal Transducing / Lung Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States