Redox-ligand sustains controlled generation of CF3 radicals by well-defined copper complex.
Chem Sci
; 7(3): 2030-2036, 2016 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-29899928
ABSTRACT
A well-defined copper complex bearing iminosemiquinone ligands performs single electron reduction of an electrophilic CF3+ source into CFË3 radicals. This redox behavior is enabled by the ligand which shuttles through two different redox states (iminosemiquinone and iminobenzoquinone) while the copper center is preserved as a Cu(ii). This system was used in the trifluoromethylation of silyl enol ethers, heteroaromatics and in the hydrotrifluoromethylation of alkynes. This is the first example of cooperative redox catalysis for the controlled generation of CFË3 radicals.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chem Sci
Year:
2016
Document type:
Article