Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype.
EuPA Open Proteom
; 10: 42-49, 2016 Mar.
Article
in En
| MEDLINE
| ID: mdl-29900099
ABSTRACT
Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
EuPA Open Proteom
Year:
2016
Document type:
Article
Affiliation country:
Italy