Management of Ocular Human herpesvirus 1 Infection in a White-faced Saki Monkey (Pithecia pithecia).
Comp Med
; 68(4): 319-323, 2018 08 01.
Article
in En
| MEDLINE
| ID: mdl-29907165
ABSTRACT
A 20-y-old male intact white-faced saki monkey (Pithecia pithecia) presented with an acute ocular disease of the right eye. Clinical signs included periocular swelling, conjunctivitis, and anisocoria with a miotic right pupil. Conjunctival swabs were positive for Human herpesvirus 1 (HHV1) according to PCR amplification with sequencing. Initial clinical signs resolved with supportive treatment, and the animal was managed chronically by using acyclovir (5 mg/kg PO twice daily) during flare-ups. After more than 2 y, the progression of clinical disease led to enucleation of the right eye. At 2 mo after surgery, acute presentation of severe neurologic signs, including ataxia and blindness, resulted in euthanasia. Histopathology, PCR analysis, and sequencing results were consistent with viral encephalitis due to HHV1; coinfection with Pithecia pithecia lymphocryptovirus 1 was identified. This report describes the first case of managed HHV1 infection in a platyrrhine primate and the first case of HHV1 in a white-faced saki monkey that was not rapidly fatal.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Eye Diseases
/
Herpes Simplex
/
Monkey Diseases
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Comp Med
Journal subject:
MEDICINA
/
MEDICINA VETERINARIA
Year:
2018
Document type:
Article
Affiliation country:
United States