Surgical and Oncologic Outcomes of Radical Abdominal Trachelectomy Versus Hysterectomy for Stage IA2-IB1 Cervical Cancer.
J Minim Invasive Gynecol
; 26(3): 484-491, 2019.
Article
in En
| MEDLINE
| ID: mdl-29908338
ABSTRACT
STUDY OBJECTIVE:
To compare the surgical and oncologic outcomes between abdominal radical trachelectomy (ART) and radical hysterectomy (RH) for stage IA2-IB1 cervical cancer.DESIGN:
A retrospective cohort study (Canadian Task Force classification II-2).SETTING:
Shandong Cancer Hospital, Shandong, China. PATIENTS Three hundred twenty-nine patients with IA2-IB1 cervical cancer.INTERVENTIONS:
All patients underwent ART or RH. MEASUREMENTS AND MAINRESULTS:
All patients were divided into ART (nâ¯=â¯143) and RH (nâ¯=â¯186) groups according to the surgical approach. Additionally, oncologic and fertility outcomes were compared for different tumor pathologies and sizes in ART patients. The ART group had similar case characteristics as the RH group, except that the ART group had a longer surgical time. During a similar follow-up period, there were 4 (2.9%) recurrences and 3 (2.2%) patients who died from recurrence in the ART group compared with 8 (4.6%) recurrences and 4 (2.3%) patients who died from recurrence in the RH group (pâ¯=â¯.444 and pâ¯=â¯.999, respectively). In the ART group, squamous cell carcinoma (SCC) patients had a 5-year overall survival and pregnancy rate similar to those of non-SCC patients (98.1% vs 96.8%, pâ¯=â¯.999; 33.3% vs 26.7%, pâ¯=â¯.873), and patients with tumors ≤2 cm and 2 to 4 cm experienced a similar 5-year overall survival rate (97.0% vs 98.6%, pâ¯=â¯.999), except patients with tumors ≤2 cm had a higher pregnancy rate (45.2% vs 17.2%, pâ¯=â¯.020).CONCLUSION:
ART seems to have similar surgical and oncologic outcomes to RH, except ART has a longer surgical time. Both non-SCC patients and stage IA2-IB1 patients with 2- to 4-cm tumors can undergo ART safely. Patients with tumors ≤2 cm have a higher pregnancy rate than patients with 2- to 4-cm tumors.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Squamous Cell
/
Uterine Cervical Neoplasms
/
Neoplasm Recurrence, Local
Type of study:
Observational_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
En
Journal:
J Minim Invasive Gynecol
Journal subject:
GINECOLOGIA
Year:
2019
Document type:
Article