Subcutaneous rather than intravenous ustekinumab induction is associated with comparable circulating drug levels and early clinical response: a pilot study.

Rowan, C R; Keegan, D; Byrne, K; Cullen, G; Mulcahy, H E; Sheridan, J; Ryan, E J; de Vries, A; D'Haens, G; Doherty, G A

Rowan, C R; Keegan, D; Byrne, K; Cullen, G; Mulcahy, H E; Sheridan, J; Ryan, E J; de Vries, A; D'Haens, G; Doherty, G A.

Affiliation

Rowan CR; Center for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.
Keegan D; Center for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.
Byrne K; Center for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.
Cullen G; Center for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.
Mulcahy HE; Center for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.
Sheridan J; Center for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.
Ryan EJ; Center for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.
de Vries A; Sanquin Diagnostic Services, Amsterdam, The Netherlands.
D'Haens G; Department of Gastroenterology, Amsterdam Medical Centre, Amsterdam, The Netherlands.
Doherty GA; Center for Colorectal Disease, St. Vincent's University Hospital, School of Medicine, University College Dublin, Dublin, Ireland.

Aliment Pharmacol Ther ; 48(3): 333-339, 2018 08.

Article in En | MEDLINE | ID: mdl-29920697

Subject(s)

Crohn Disease/drug therapy; Induction Chemotherapy/methods; Ustekinumab/administration & dosage; Ustekinumab/blood; Administration, Intravenous; Adult; Cohort Studies; Crohn Disease/diagnosis; Crohn Disease/metabolism; Female; Humans; Injections, Subcutaneous; Male; Off-Label Use; Pilot Projects; Remission Induction; Time Factors; Treatment Outcome; Ustekinumab/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease / Induction Chemotherapy / Ustekinumab Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male Language: En Journal: Aliment Pharmacol Ther Journal subject: FARMACOLOGIA / GASTROENTEROLOGIA / TERAPIA POR MEDICAMENTOS Year: 2018 Document type: Article Affiliation country: Ireland Country of publication: United kingdom

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