Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia.

Zorina, Yana; Stricker, Jason; Caggiano, Anthony O; Button, Donald C

Zorina, Yana; Stricker, Jason; Caggiano, Anthony O; Button, Donald C.

Affiliation

Zorina Y; Gene Editing and Screening Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Stricker J; Translational Medicine, Celgene Corporation, Summit, NJ, USA.
Caggiano AO; Research and Development, Acorda Therapeutics Inc., Ardsley, NY, USA.
Button DC; PharmAble, San Francisco, CA, USA. donb@fastmail.com.

Sci Rep ; 8(1): 9392, 2018 06 20.

Article in En | MEDLINE | ID: mdl-29925848

Subject(s)

Antibodies/immunology; Antibodies/metabolism; Immunoglobulin M/immunology; Microglia/cytology; Microglia/metabolism; Myelin Sheath/metabolism; Animals; Cell Differentiation/physiology; Cell Line; Cells, Cultured; Humans; Mice; Phagocytes/cytology; Phagocytes/metabolism; Phagocytosis/physiology; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin M / Microglia / Antibodies / Myelin Sheath Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2018 Document type: Article Affiliation country: United States Country of publication: United kingdom

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