International experience with minocycline, EDTA and ethanol lock for salvaging of central line associated bloodstream infections.
Expert Rev Med Devices
; 15(6): 461-466, 2018 Jun.
Article
in En
| MEDLINE
| ID: mdl-29927699
ABSTRACT
BACKGROUND:
The use of long-term central venous catheters (CVCs) could lead to serious bloodstream infections. Removal of the infected CVC and reinsertion of a new CVC are not always feasible and alternative lock therapy may be considered. We conducted a multicenter trial to assess the efficacy and safety of the lock therapy.METHODS:
Between October 2013 and August 2014, we prospectively enrolled 20 patients with catheter-related bloodstream infections (CRBSIs) or central line-associated bloodstream infections (CLABSIs) in our sister institutions in three countries including Brazil, Lebanon, and Japan. The 20 patients who received M-EDTA-EtOH lock therapy were compared to 24 control patients who had their CVCs removed and a new CVC inserted.RESULTS:
Both groups had comparable clinical characteristics. In the lock therapy group, 95% of the patients had microbiological eradication within 96 h after starting lock therapy versus 83% of the patients in the control group (p = .36). In the lock group, the CVC was salvaged and retained for a median of 21 days (range 7-51) from the onset of bacteremia.CONCLUSION:
Our study suggests that M-EDTA-EtOH lock therapy may be an effective intervention to salvage long-term CVCs in the setting of CLABSI/CRBSI and hemodialysis cancer patients with limited vascular access.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacteremia
/
Edetic Acid
/
Ethanol
/
Minocycline
Type of study:
Clinical_trials
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Expert Rev Med Devices
Journal subject:
DIAGNOSTICO POR IMAGEM
/
TERAPEUTICA
Year:
2018
Document type:
Article
Affiliation country:
United States