Selective Synthesis of Unsymmetrical Aliphatic Acyloins through Oxidation of Iridium Enolates.
Chemistry
; 24(45): 11564-11567, 2018 Aug 09.
Article
in En
| MEDLINE
| ID: mdl-29928782
ABSTRACT
The first method to access unsymmetrical aliphatic acyloins is presented. The method relies on a fast 1,3-hydride shift mediated by an IrIII complex in allylic alcohols followed by oxidation with TEMPO+ . The direct conversion of allylic alcohols into acyloins is achieved in a one-pot procedure. Further functionalization of the Cα' of the α-amino-oxylated ketone products gives access to highly functionalized unsymmetrical aliphatic ketones, which further highlights the utility of this transformation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Chemistry
Journal subject:
QUIMICA
Year:
2018
Document type:
Article
Affiliation country:
Sweden