Development of a Broadly Applicable Assay for Measurement of Glycan-Directed Enzymatic Activity.

Bresciani, Alberto; Cecchetti, Ottavia; Missineo, Antonino; Pacifici, Pier Giorgio; Tomei, Licia; Rodems, Steven

Bresciani, Alberto; Cecchetti, Ottavia; Missineo, Antonino; Pacifici, Pier Giorgio; Tomei, Licia; Rodems, Steven.

Affiliation

Bresciani A; 1 IRBM Science Park SpA, Pomezia (Roma), Italy.
Cecchetti O; 1 IRBM Science Park SpA, Pomezia (Roma), Italy.
Missineo A; 1 IRBM Science Park SpA, Pomezia (Roma), Italy.
Pacifici PG; 1 IRBM Science Park SpA, Pomezia (Roma), Italy.
Tomei L; 1 IRBM Science Park SpA, Pomezia (Roma), Italy.
Rodems S; 2 Retrophin, Inc., San Diego, CA, USA.

SLAS Discov ; 23(9): 941-950, 2018 10.

Article in En | MEDLINE | ID: mdl-29932789

Subject(s)

Biological Assay/methods; Enzymes/metabolism; Polysaccharides/metabolism; Drug Discovery; Enzyme Activation; Fluorescence Resonance Energy Transfer; Glycosylation; Humans; Surface Plasmon Resonance

Key words

activity assay; deglycosylation; drug discovery; glycobiology; screening

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides / Biological Assay / Enzymes Limits: Humans Language: En Journal: SLAS Discov Year: 2018 Document type: Article Affiliation country: Italy Country of publication: United States

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