Relationship between CYP1B1 polymorphisms (c.142C > G, c.355G > T, c.1294C > G) and lung cancer risk in Polish smokers.
Future Oncol
; 14(16): 1569-1577, 2018 Jul.
Article
in En
| MEDLINE
| ID: mdl-29938532
ABSTRACT
AIM:
To determine whether three of CYP1B1 single nucleotide polymorphisms, c.142C > G, c.355G > T and c.1294C > G are associated with a lung cancer risk. PATIENTS &METHODS:
A total of 112 lung cancer patients and 100 controls were genotyped using the RFLP-PCR.RESULTS:
In the c.142C > G polymorphisms, G allele was more frequent in lung cancer patients than in controls (p < 0.001), while in the c.1294C > G polymorphisms, C allele was more frequent in lung cancer patients, than in controls (p = 0.012). In the c.355G > T polymorphism, the distribution of alleles in both analyzed groups was similar. The GTC haplotype turned out to be correlated with the increased lung cancer risk, compared with the most common CGG haplotype (OR 2.38; p = 0.001).CONCLUSION:
CYP1B1 gene polymorphisms appear to influence lung cancer susceptibility.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Single Nucleotide
/
Cytochrome P-450 CYP1B1
/
Smokers
/
Lung Neoplasms
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Future Oncol
Year:
2018
Document type:
Article
Affiliation country:
Poland