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A novel cytochrome P450 mono-oxygenase from Streptomyces platensis resembles activities of human drug metabolizing P450s.
Worsch, Anne; Eggimann, Fabian Kurt; Girhard, Marco; von Bühler, Clemens J; Tieves, Florian; Czaja, Rico; Vogel, Andreas; Grumaz, Christian; Sohn, Kai; Lütz, Stephan; Kittelmann, Matthias; Urlacher, Vlada B.
Affiliation
  • Worsch A; Heinrich Heine University Düsseldorf, Institute of Biochemistry, Düsseldorf, Germany.
  • Eggimann FK; Novartis Pharma AG, Basel, Switzerland.
  • Girhard M; Heinrich Heine University Düsseldorf, Institute of Biochemistry, Düsseldorf, Germany.
  • von Bühler CJ; Heinrich Heine University Düsseldorf, Institute of Biochemistry, Düsseldorf, Germany.
  • Tieves F; Present address: Bayer AG, Drug Discovery, Pharmaceuticals DM, Wuppertal, Germany.
  • Czaja R; Heinrich Heine University Düsseldorf, Institute of Biochemistry, Düsseldorf, Germany.
  • Vogel A; Present address: Department of Biotechnology, Delft University of Technology, Delft, The Netherlands.
  • Grumaz C; c-LEcta GmbH, Leipzig, Germany.
  • Sohn K; c-LEcta GmbH, Leipzig, Germany.
  • Lütz S; Department of Molecular Biotechnology, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart, Germany.
  • Kittelmann M; Department of Molecular Biotechnology, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Stuttgart, Germany.
  • Urlacher VB; Novartis Pharma AG, Basel, Switzerland.
Biotechnol Bioeng ; 115(9): 2156-2166, 2018 09.
Article in En | MEDLINE | ID: mdl-29943426
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Xenobiotics / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases Limits: Humans Language: En Journal: Biotechnol Bioeng Year: 2018 Document type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptomyces / Xenobiotics / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases Limits: Humans Language: En Journal: Biotechnol Bioeng Year: 2018 Document type: Article Affiliation country: Germany