GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location.
Eur J Histochem
; 62(2): 2931, 2018 Jun 14.
Article
in En
| MEDLINE
| ID: mdl-29943957
ABSTRACT
Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Neoplasms
/
Immunohistochemistry
/
Adenocarcinoma
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N-Acetylgalactosaminyltransferases
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
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Aged80
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
Eur J Histochem
Journal subject:
HISTOCITOQUIMICA
Year:
2018
Document type:
Article