Transformative Opportunities for Single-Cell Proteomics.
J Proteome Res
; 17(8): 2565-2571, 2018 08 03.
Article
in En
| MEDLINE
| ID: mdl-29945450
ABSTRACT
Many pressing medical challenges, such as diagnosing disease, enhancing directed stem-cell differentiation, and classifying cancers, have long been hindered by limitations in our ability to quantify proteins in single cells. Mass spectrometry (MS) is poised to transcend these limitations by developing powerful methods to routinely quantify thousands of proteins and proteoforms across many thousands of single cells. We outline specific technological developments and ideas that can increase the sensitivity and throughput of single-cell MS by orders of magnitude and usher in this new age. These advances will transform medicine and ultimately contribute to understanding biological systems on an entirely new level.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dietary Proteins
/
Proteomics
/
Single-Cell Analysis
Limits:
Animals
/
Humans
Language:
En
Journal:
J Proteome Res
Journal subject:
BIOQUIMICA
Year:
2018
Document type:
Article
Affiliation country:
United States