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Discovery of a Potent, Orally Bioavailable PI4KIIIß Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo.
Reuberson, James; Horsley, Helen; Franklin, Richard J; Ford, Daniel; Neuss, Judi; Brookings, Daniel; Huang, Qiuya; Vanderhoydonck, Bart; Gao, Ling-Jie; Jang, Mi-Yeon; Herdewijn, Piet; Ghawalkar, Anant; Fallah-Arani, Farnaz; Khan, Adnan R; Henshall, Jamie; Jairaj, Mark; Malcolm, Sarah; Ward, Eleanor; Shuttleworth, Lindsay; Lin, Yuan; Li, Shengqiao; Louat, Thierry; Waer, Mark; Herman, Jean; Payne, Andrew; Ceska, Tom; Doyle, Carl; Pitt, Will; Calmiano, Mark; Augustin, Martin; Steinbacher, Stefan; Lammens, Alfred; Allen, Rodger.
Affiliation
  • Reuberson J; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Horsley H; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Franklin RJ; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Ford D; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Neuss J; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Brookings D; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Huang Q; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Vanderhoydonck B; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Gao LJ; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Jang MY; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Herdewijn P; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Ghawalkar A; SAI Life Sciences Ltd , International Biotech Park , Hinjewadi, Pune 411 057 , India.
  • Fallah-Arani F; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Khan AR; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Henshall J; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Jairaj M; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Malcolm S; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Ward E; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Shuttleworth L; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Lin Y; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Li S; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Louat T; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Waer M; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Herman J; Interface Valorization Platform , KU Leuven , Campus St.-Rafaël, Blok I, 8°, Kapucijnenvoer 33 B 7001 , 3000 Leuven , Belgium.
  • Payne A; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Ceska T; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Doyle C; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Pitt W; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Calmiano M; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
  • Augustin M; Proteros Biostructures GmbH , Bunsenstrasse 7a , 82152 Martinsried , Germany.
  • Steinbacher S; Proteros Biostructures GmbH , Bunsenstrasse 7a , 82152 Martinsried , Germany.
  • Lammens A; Proteros Biostructures GmbH , Bunsenstrasse 7a , 82152 Martinsried , Germany.
  • Allen R; UCB Pharma , 208 Bath Road , Slough , Berkshire SL1 3WE , United Kingdom.
J Med Chem ; 61(15): 6705-6723, 2018 08 09.
Article in En | MEDLINE | ID: mdl-29952567
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Piperidines / Transplantation, Homologous / Phosphotransferases (Alcohol Group Acceptor) / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United kingdom Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Piperidines / Transplantation, Homologous / Phosphotransferases (Alcohol Group Acceptor) / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: United kingdom Country of publication: United States