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Combination of APD668, a G protein-coupled receptor 119 agonist with linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in a murine model of non-alcoholic steatohepatitis with diabetes.
Bahirat, Umakant Ashok; Talwar, Rashmi; Shenoy, Rekha Raghuveer; Nemmani, Kumar V S; Goel, Rajan Naresh.
Affiliation
  • Bahirat UA; Department of Pharmacology, Novel Drug Discovery and Development (NDDD), Lupin Limited (Research Park), 46A/47A, Village Nande, Taluka Mulshi, Pune, Maharashtra, 412115, India. umakantbahirat@lupin.com.
  • Talwar R; Department of Pharmacology, Novel Drug Discovery and Development (NDDD), Lupin Limited (Research Park), 46A/47A, Village Nande, Taluka Mulshi, Pune, Maharashtra, 412115, India.
  • Shenoy RR; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
  • Nemmani KVS; Department of Pharmacology, Novel Drug Discovery and Development (NDDD), Lupin Limited (Research Park), 46A/47A, Village Nande, Taluka Mulshi, Pune, Maharashtra, 412115, India.
  • Goel RN; Department of Pharmacology, Novel Drug Discovery and Development (NDDD), Lupin Limited (Research Park), 46A/47A, Village Nande, Taluka Mulshi, Pune, Maharashtra, 412115, India.
Med Mol Morphol ; 52(1): 36-43, 2019 Mar.
Article in En | MEDLINE | ID: mdl-29959534
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Diabetes Mellitus, Experimental / Non-alcoholic Fatty Liver Disease / Linagliptin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Med Mol Morphol Journal subject: BIOLOGIA MOLECULAR / PATOLOGIA Year: 2019 Document type: Article Affiliation country: India Country of publication: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Diabetes Mellitus, Experimental / Non-alcoholic Fatty Liver Disease / Linagliptin Type of study: Prognostic_studies Limits: Animals Language: En Journal: Med Mol Morphol Journal subject: BIOLOGIA MOLECULAR / PATOLOGIA Year: 2019 Document type: Article Affiliation country: India Country of publication: Japan