Adaptor Proteins, Signal Transducing/metabolism; Autism Spectrum Disorder/genetics; Autism Spectrum Disorder/metabolism; Cell Adhesion Molecules, Neuronal/genetics; Cell Adhesion Molecules, Neuronal/metabolism; Extracellular Matrix Proteins/genetics; Extracellular Matrix Proteins/metabolism; Genetic Variation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Serine Endopeptidases/genetics; Serine Endopeptidases/metabolism; Signal Transduction; Adaptor Proteins, Signal Transducing/chemistry; Alleles; Autism Spectrum Disorder/diagnosis; Biomarkers; Case-Control Studies; Cell Adhesion Molecules, Neuronal/chemistry; Child; Child, Preschool; Extracellular Matrix Proteins/chemistry; Female; Gene Expression; Heterozygote; Humans; Induced Pluripotent Stem Cells/cytology; Induced Pluripotent Stem Cells/metabolism; Male; Models, Molecular; Nerve Tissue Proteins/chemistry; Neural Stem Cells/cytology; Neural Stem Cells/metabolism; Protein Conformation; Proto-Oncogene Proteins c-akt/metabolism; Reelin Protein; Serine Endopeptidases/chemistry; Structure-Activity Relationship; TOR Serine-Threonine Kinases/metabolism

Reelin-DAB1 signaling; autism spectrum disorder; functional analysis of rare variants; iPSC-derived neural progenitor cells; mTORC1 signaling