Recurrence after fertility-preserving surgery for low-grade endometrial stromal sarcoma.
J Obstet Gynaecol Res
; 44(9): 1836-1842, 2018 Sep.
Article
in En
| MEDLINE
| ID: mdl-29974555
ABSTRACT
Considering the characteristics of low-grade endometrial stromal sarcoma (ESS), such as relative indolent course, younger age at diagnosis and favorable prognosis, the fertility-preserving management of low-grade ESS has been described by several authors. We report a 34-year-old female with stage IB low-grade ESS who developed recurrence 7 years after neoadjuvant high-dose progestin therapy followed by fertility-preserving surgery and postoperative progestin therapy. The patient stopped progestin therapy and was disease free for 4 years after diagnosis but experienced recurrence with peritoneal dissemination at 7 years. Considering the tendency of late recurrence, long-term surveillance is necessary to ensure timely action. Long-term progestin treatment might be considered after complete remission even beyond 5 years. We performed a literature review and found that many of the cases did not meet solid pathological criteria of low-grade ESS. The diagnostic criteria of low-grade ESS (vs endometrial stromal nodule) should be deliberately documented for future studies of this rare disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Progestins
/
Endometrial Neoplasms
/
Endometrial Stromal Tumors
/
Fertility Preservation
/
Neoplasm Recurrence, Local
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
J Obstet Gynaecol Res
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
2018
Document type:
Article
Affiliation country:
Taiwan