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On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin.
Medve, Laura; Achilli, Silvia; Serna, Sonia; Zuccotto, Fabio; Varga, Norbert; Thépaut, Michel; Civera, Monica; Vivès, Corinne; Fieschi, Franck; Reichardt, Niels; Bernardi, Anna.
Affiliation
  • Medve L; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133, Milano, Italy.
  • Achilli S; Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000, Grenoble, France.
  • Serna S; Glycotechnology laboratory, CIC biomaGUNE, Paseo Miramón 182, 20014, Donostia-San Sebastián, Spain.
  • Zuccotto F; University of Dundee, Dundee, UK.
  • Varga N; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133, Milano, Italy.
  • Thépaut M; Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000, Grenoble, France.
  • Civera M; Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133, Milano, Italy.
  • Vivès C; Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000, Grenoble, France.
  • Fieschi F; Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000, Grenoble, France.
  • Reichardt N; Glycotechnology laboratory, CIC biomaGUNE, Paseo Miramón 182, 20014, Donostia-San Sebastián, Spain.
  • Bernardi A; CIBER-BBN, 20014, Donostia-San Sebastián, Spain.
Chemistry ; 24(54): 14448-14460, 2018 Sep 25.
Article in En | MEDLINE | ID: mdl-29975429
A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Italy Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2018 Document type: Article Affiliation country: Italy Country of publication: Germany