Label-free tracking of nanosized graphene oxide cellular uptake by confocal Raman microscopy.
Analyst
; 143(15): 3686-3692, 2018 Jul 23.
Article
in En
| MEDLINE
| ID: mdl-29978167
ABSTRACT
Graphene oxide (GO), a partially oxidized two-dimensional allotrope of carbon, is an attractive nanocarrier for cancer diagnostics and therapy. The nanometer-sized GO is known to permeate cell membranes. Herein we studied the cellular uptake pathways of GO nanoflakes by cancer and non-cancerous cell lines. By employing confocal Raman imaging, we were able to track the GO cellular uptake in living cells (C33 and MDCK) without any additional fluorescent or plasmonic labels. This specific progress in label-free Raman imaging of GO facilitates the monitoring of nanoflakes at the cellular level.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spectrum Analysis, Raman
/
Microscopy, Confocal
/
Nanoparticles
/
Graphite
Limits:
Animals
/
Humans
Language:
En
Journal:
Analyst
Year:
2018
Document type:
Article
Affiliation country:
Slovakia
Country of publication:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM