Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation.
Toxicol Sci
; 165(1): 14-20, 2018 09 01.
Article
in En
| MEDLINE
| ID: mdl-29982725
ABSTRACT
Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain development can be disassembled into several neurodevelopmental endpoints which can be represented by a combination of different alternative assays. In this review article, we provide a scientific rationale for the neurodevelopmental endpoints that are currently chosen to establish assays with human stem/and progenitor cells. Assays covering these major neurodevelopmental endpoints are thought to assemble as building blocks of a DNT testing battery.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Toxicity Tests
/
Embryonic Stem Cells
/
Neurogenesis
/
Neural Stem Cells
Type of study:
Etiology_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Toxicol Sci
Journal subject:
TOXICOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
Germany