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Design and Amberlyst-15 mediated synthesis of novel thienyl-pyrazole carboxamides that potently inhibit Phospholipase A2 by binding to an allosteric site on the enzyme.
Kumar, Achutha Dileep; Prabhudeva, Malledevarapura Gurumurthy; Bharath, Srinivasan; Kumara, Karthik; Lokanath, Neratur Krishnappagowda; Kumar, Kariyappa Ajay.
Affiliation
  • Kumar AD; Department of Chemistry, Yuvaraja College, University of Mysore, Mysuru 570005, India.
  • Prabhudeva MG; Department of Chemistry, Yuvaraja College, University of Mysore, Mysuru 570005, India.
  • Bharath S; Marie Sklodowska-Curie Actions Fellow, Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal.
  • Kumara K; Department of Studies in Physics, University of Mysore, Mysuru 570006, India.
  • Lokanath NK; Department of Studies in Physics, University of Mysore, Mysuru 570006, India.
  • Kumar KA; Department of Chemistry, Yuvaraja College, University of Mysore, Mysuru 570005, India. Electronic address: ajaykumar@ycm.uni-mysore.ac.in.
Bioorg Chem ; 80: 444-452, 2018 10.
Article in En | MEDLINE | ID: mdl-29986189
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Daboia / Allosteric Site / Group II Phospholipases A2 / Phospholipase A2 Inhibitors Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Bioorg Chem Year: 2018 Document type: Article Affiliation country: India Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Daboia / Allosteric Site / Group II Phospholipases A2 / Phospholipase A2 Inhibitors Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Bioorg Chem Year: 2018 Document type: Article Affiliation country: India Country of publication: United States