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Senolytics improve physical function and increase lifespan in old age.
Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N; Weigand, Bettina M; Palmer, Allyson K; Weivoda, Megan M; Inman, Christina L; Ogrodnik, Mikolaj B; Hachfeld, Christine M; Fraser, Daniel G; Onken, Jennifer L; Johnson, Kurt O; Verzosa, Grace C; Langhi, Larissa G P; Weigl, Moritz; Giorgadze, Nino; LeBrasseur, Nathan K; Miller, Jordan D; Jurk, Diana; Singh, Ravinder J; Allison, David B; Ejima, Keisuke; Hubbard, Gene B; Ikeno, Yuji; Cubro, Hajrunisa; Garovic, Vesna D; Hou, Xiaonan; Weroha, S John; Robbins, Paul D; Niedernhofer, Laura J; Khosla, Sundeep; Tchkonia, Tamara; Kirkland, James L.
Affiliation
  • Xu M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. mixu@uchc.edu.
  • Pirtskhalava T; University of Connecticut Center on Aging, University of Connecticut Health, Farmington, CT, USA. mixu@uchc.edu.
  • Farr JN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Weigand BM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Palmer AK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Weivoda MM; Newcastle University Institute for Ageing and Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Ogrodnik MB; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Hachfeld CM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Fraser DG; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Onken JL; Newcastle University Institute for Ageing and Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Verzosa GC; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Langhi LGP; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Weigl M; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Miller JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Jurk D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Singh RJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Allison DB; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Ejima K; Newcastle University Institute for Ageing and Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK.
  • Hubbard GB; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
  • Ikeno Y; Department of Epidemiology & Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA.
  • Cubro H; Nathan Shock Center on Comparative Energetics and Aging, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Garovic VD; Department of Epidemiology & Biostatistics, School of Public Health, Indiana University-Bloomington, Bloomington, IN, USA.
  • Hou X; Nathan Shock Center on Comparative Energetics and Aging, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Weroha SJ; Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Robbins PD; Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Niedernhofer LJ; Geriatric Research Education and Clinical Center, South Texas Veterans Healthcare System, San Antonio, TX, USA.
  • Khosla S; Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
  • Tchkonia T; Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
  • Kirkland JL; Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Nat Med ; 24(8): 1246-1256, 2018 08.
Article in En | MEDLINE | ID: mdl-29988130

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quercetin / Dasatinib / Longevity Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quercetin / Dasatinib / Longevity Limits: Animals Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States