Metal-Organic Frameworks as Efficient Oral Detoxifying Agents.
J Am Chem Soc
; 140(30): 9581-9586, 2018 08 01.
Article
in En
| MEDLINE
| ID: mdl-29989808
ABSTRACT
Poisoning and accidental oral intoxication are major health problems worldwide. Considering the insufficient efficacy of the currently available detoxification treatments, a pioneering oral detoxifying adsorbent agent based on a single biocompatible metal-organic framework (MOF) is here proposed for the efficient decontamination of drugs commonly implicated in accidental or voluntary poisoning. Furthermore, the in vivo toxicity and biodistribution of a MOF via oral administration have been investigated for the first time. Orally administered upon a salicylate overdose, this MOF is able to reduce the salicylate gastrointestinal absorption and toxicity more than 40-fold (avoiding histological damage) while exhibiting exceptional gastrointestinal stability (<9% degradation), poor intestinal permeation, and safety.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aspirin
/
Drug Overdose
/
Metal-Organic Frameworks
/
Antidotes
Limits:
Animals
Language:
En
Journal:
J Am Chem Soc
Year:
2018
Document type:
Article
Affiliation country:
France