Roles of PIP2 in the membrane binding of MIM I-BAR: insights from molecular dynamics simulations.
FEBS Lett
; 592(15): 2533-2542, 2018 08.
Article
in En
| MEDLINE
| ID: mdl-29995324
ABSTRACT
In order to probe the roles of PIP2 in the interactions between MIM I-BAR and model membranes, we performed a series of 10 µs-scale coarse-grained molecular dynamics simulations. Our results indicate that PIP2 plays predominant roles in the membrane binding of MIM I-BAR in a concentration-dependent manner and via electrostatic interactions. Besides, we find that the occurrence of the membrane curvature may induce the re-distribution of lipids in the membrane and result in the local enrichment of PIP2 at negatively curved membrane areas. Combining these roles of PIP2 in the membrane binding of MIM I-BAR helps explain how MIM I-BAR senses negative curvature and, thus, contributes to maintaining membrane protrusions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Membrane
/
Inositol Phosphates
/
Microfilament Proteins
/
Neoplasm Proteins
Limits:
Humans
Language:
En
Journal:
FEBS Lett
Year:
2018
Document type:
Article
Affiliation country:
China