Genetic inactivation of synaptosomal-associated protein 25 (SNAP-25) in adult hippocampal neural progenitors impairs pattern discrimination learning but not survival or structural maturation of newborn dentate granule cells.

Gustus, Kymberly C; Li, Lu; Chander, Praveen; Weick, Jason P; Wilson, Michael C; Cunningham, Lee Anna

Gustus, Kymberly C; Li, Lu; Chander, Praveen; Weick, Jason P; Wilson, Michael C; Cunningham, Lee Anna.

Affiliation

Gustus KC; Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Li L; Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Chander P; Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Weick JP; Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Wilson MC; Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.
Cunningham LA; Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico.

Hippocampus ; 28(10): 735-744, 2018 10.

Article in En | MEDLINE | ID: mdl-29995325

Subject(s)

Hippocampus/cytology; Hippocampus/growth & development; Learning Disabilities/genetics; Neurogenesis/physiology; Neurons/physiology; Synaptosomal-Associated Protein 25/deficiency; Animals; Animals, Newborn; Cells, Cultured; Discrimination Learning/drug effects; Discrimination Learning/physiology; Excitatory Postsynaptic Potentials/drug effects; Excitatory Postsynaptic Potentials/genetics; Fear/physiology; Glutamic Acid/pharmacology; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Learning Disabilities/pathology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nestin/genetics; Nestin/metabolism; Neurons/drug effects; Phosphopyruvate Hydratase/metabolism; RNA, Messenger/metabolism; Synaptosomal-Associated Protein 25/genetics; Transfection

Key words

Adult hippocampal neurogenesis; contextual fear discrimination; memory; synaptic neurotransmission; time

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synaptosomal-Associated Protein 25 / Neurogenesis / Hippocampus / Learning Disabilities / Neurons Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Hippocampus Journal subject: CEREBRO Year: 2018 Document type: Article Country of publication: United States

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