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Viral metagenomics, genetic and evolutionary characteristics of Crimean-Congo hemorrhagic fever orthonairovirus in humans, Kosovo.
Emmerich, Petra; Jakupi, Xhevat; von Possel, Ronald; Berisha, Lindita; Halili, Bahrije; Günther, Stephan; Cadar, Daniel; Ahmeti, Salih; Schmidt-Chanasit, Jonas.
Affiliation
  • Emmerich P; Department of Virology, Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany; University of Rostock, Rostock, Germany.
  • Jakupi X; National Institute for Public Health of Kosova, Prishtina, Kosovo.
  • von Possel R; Department of Virology, Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany.
  • Berisha L; University Clinical Center of Kosovo, Infectious Diseases Clinic, Prishtina, Kosovo.
  • Halili B; University Clinical Center of Kosovo, Infectious Diseases Clinic, Prishtina, Kosovo.
  • Günther S; Department of Virology, Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany; German Centre for Infection Research (DZIF), Hamburg, Germany.
  • Cadar D; Department of Arbovirology, Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany; German Centre for Infection Research (DZIF), Hamburg, Germany. Electronic address: danielcadar@gmail.com.
  • Ahmeti S; National Institute for Public Health of Kosova, Prishtina, Kosovo.
  • Schmidt-Chanasit J; Department of Arbovirology, Bernhard Nocht Institute for Tropical Medicine, WHO Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany; German Centre for Infection Research (DZIF), Hamburg, Germany.
Infect Genet Evol ; 65: 6-11, 2018 11.
Article in En | MEDLINE | ID: mdl-30006045
ABSTRACT
Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a tick-borne virus which causes severe disease in humans with fatality cases up to 30%. We investigated the genetic and evolutionary characteristics of CCHFV in Kosovo, in particular in humans and found that different virus variants of genotype V circulate, with Turkey as a possible origin for the progenitor of southern European CCHF outbreaks. Phylogenetic analyses also revealed a single introduction event and in situ evolution of CCHFV in this country. The viral metagenomics revealed a more abundant virome in the fatal CCHF cases and the presence of a novel tick-borne segmented RNA virus belonging to the recently discovered Jingmenvirus group which raises questions about the potential pathogenic effect of this novel virus on human and animal health.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genome, Viral / Hemorrhagic Fever Virus, Crimean-Congo / Evolution, Molecular / Metagenomics / Hemorrhagic Fever, Crimean Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Infect Genet Evol Journal subject: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Year: 2018 Document type: Article Affiliation country: Germany
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genome, Viral / Hemorrhagic Fever Virus, Crimean-Congo / Evolution, Molecular / Metagenomics / Hemorrhagic Fever, Crimean Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: En Journal: Infect Genet Evol Journal subject: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Year: 2018 Document type: Article Affiliation country: Germany