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Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus.
Fujieda, Hiroki; Kogami, Masakazu; Sakairi, Masao; Kato, Noriyasu; Makino, Mitsuhiro; Takahashi, Naoki; Miyazawa, Toshiyuki; Harada, Satoko; Yamashita, Tokuyuki.
Affiliation
  • Fujieda H; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan. Electronic address: h_fujieda@skk-net.com.
  • Kogami M; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan.
  • Sakairi M; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan.
  • Kato N; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan.
  • Makino M; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan.
  • Takahashi N; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan.
  • Miyazawa T; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan.
  • Harada S; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan.
  • Yamashita T; Drug Discovery Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki, Hokusei-cho, Inabe-shi, Mie, 511-0406, Japan.
Eur J Med Chem ; 156: 269-294, 2018 Aug 05.
Article in En | MEDLINE | ID: mdl-30006171
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Thiophenes / Enzyme Activators / Diabetes Mellitus, Type 2 / Glucokinase / Hypoglycemic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2018 Document type: Article Country of publication: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidines / Thiophenes / Enzyme Activators / Diabetes Mellitus, Type 2 / Glucokinase / Hypoglycemic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Eur J Med Chem Year: 2018 Document type: Article Country of publication: France