Cathepsin B inhibition ameliorates the non-alcoholic steatohepatitis through suppressing caspase-1 activation.

Tang, Yong; Cao, Guojun; Min, Xiaobo; Wang, Tao; Sun, Shiran; Du, Xiaolong; Zhang, Weikang

Tang, Yong; Cao, Guojun; Min, Xiaobo; Wang, Tao; Sun, Shiran; Du, Xiaolong; Zhang, Weikang.

Affiliation

Tang Y; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Cao G; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Min X; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Wang T; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Sun S; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Du X; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zhang W; Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. weikang_zhang11@126.com.

J Physiol Biochem ; 74(4): 503-510, 2018 Nov.

Article in En | MEDLINE | ID: mdl-30019185

Subject(s)

Caspase 1/metabolism; Cathepsin B/antagonists & inhibitors; Cysteine Proteinase Inhibitors/therapeutic use; Dipeptides/therapeutic use; Disease Models, Animal; Liver/drug effects; Non-alcoholic Fatty Liver Disease/drug therapy; Animals; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Caspase 1/chemistry; Cathepsin B/metabolism; Cells, Cultured; Cysteine Proteinase Inhibitors/administration & dosage; Dipeptides/administration & dosage; Enzyme Activation/drug effects; Fluorescent Antibody Technique, Indirect; Immunohistochemistry; Inflammasomes/drug effects; Inflammasomes/immunology; Inflammasomes/metabolism; Injections, Intraperitoneal; Interleukin-18/antagonists & inhibitors; Interleukin-18/blood; Interleukin-1beta/blood; Interleukin-1beta/metabolism; Kupffer Cells/drug effects; Kupffer Cells/immunology; Kupffer Cells/metabolism; Kupffer Cells/pathology; Liver/immunology; Liver/metabolism; Liver/pathology; Male; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein/agonists; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors; NLR Family, Pyrin Domain-Containing 3 Protein/genetics; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Non-alcoholic Fatty Liver Disease/immunology; Non-alcoholic Fatty Liver Disease/metabolism; Non-alcoholic Fatty Liver Disease/pathology; Random Allocation

Key words

Cathepsin B; Kupffer cell; NLRP3 inflammasome; Non-alcoholic fatty liver disease

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cathepsin B / Cysteine Proteinase Inhibitors / Caspase 1 / Dipeptides / Disease Models, Animal / Non-alcoholic Fatty Liver Disease / Liver Type of study: Prognostic_studies Language: En Journal: J Physiol Biochem Journal subject: BIOQUIMICA / FISIOLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: Spain

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