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Clinical validation of the next-generation sequencing-based Extended RAS Panel assay using metastatic colorectal cancer patient samples from the phase 3 PRIME study.
Udar, Nitin; Lofton-Day, Catherine; Dong, Jun; Vavrek, Darcy; Jung, A Scott; Meier, Kristen; Iyer, Anita; Slaughter, Ryan; Gutekunst, Karen; Bach, Bruce A; Peeters, Marc; Douillard, Jean-Yves.
Affiliation
  • Udar N; Department of Clinical Genomics Assay Development, Oncology, Illumina, Inc., 5200 Illumina Way, San Diego, CA, 92122, USA. greatbioinformatics@yahoo.com.
  • Lofton-Day C; Department of Medical Sciences, Amgen Inc., Thousand Oaks, CA, USA.
  • Dong J; Department of Biostatistical Sciences, Amgen Inc., Thousand Oaks, CA, USA.
  • Vavrek D; Department of Biostatistics, Illumina, Inc., San Diego, CA, USA.
  • Jung AS; Department of Research and Development, Amgen Inc., Thousand Oaks, CA, USA.
  • Meier K; Department of Biostatistics, Illumina, Inc., San Diego, CA, USA.
  • Iyer A; Department of Clinical Genomics Assay Development, Oncology, Illumina, Inc., 5200 Illumina Way, San Diego, CA, 92122, USA.
  • Slaughter R; Department of Clinical Affairs, Illumina, Inc., San Diego, CA, USA.
  • Gutekunst K; Department of Clinical Genomics Assay Development, Oncology, Illumina, Inc., 5200 Illumina Way, San Diego, CA, 92122, USA.
  • Bach BA; Department of Global Oncology Development, Amgen Inc., Thousand Oaks, CA, USA.
  • Peeters M; Department of Oncology, Antwerp University Hospital, Edegem, Belgium.
  • Douillard JY; Department of Medical Oncology, ICO René Gauducheau, Nantes, France.
J Cancer Res Clin Oncol ; 144(10): 2001-2010, 2018 Oct.
Article in En | MEDLINE | ID: mdl-30019318

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Biomarkers, Tumor / Ras Proteins / High-Throughput Nucleotide Sequencing / Liver Neoplasms / Mutation Type of study: Clinical_trials / Guideline / Prognostic_studies Limits: Humans Language: En Journal: J Cancer Res Clin Oncol Year: 2018 Document type: Article Affiliation country: United States Country of publication: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Biomarkers, Tumor / Ras Proteins / High-Throughput Nucleotide Sequencing / Liver Neoplasms / Mutation Type of study: Clinical_trials / Guideline / Prognostic_studies Limits: Humans Language: En Journal: J Cancer Res Clin Oncol Year: 2018 Document type: Article Affiliation country: United States Country of publication: Germany