Serum lipophilic antioxidants levels are associated with leucocyte telomere length among US adults.
Lipids Health Dis
; 17(1): 164, 2018 Jul 20.
Article
in En
| MEDLINE
| ID: mdl-30029639
ABSTRACT
BACKGROUND:
To examine the association between serum concentrations of antioxidant and telomere length (TL) in U.S adults.METHODS:
Participants of the National Health and Nutrition Examination Survey (NHANES) with data available on TL measures from 2001 to 2002 were included. Serum lipophilic antioxidants level was measured using high performance liquid chromatography with photodiode array detection. We used analysis of co-variance and multivariable-adjusted linear regression models, accounting for the survey design and sample weights.RESULTS:
Of the 5992 eligible participants, 47.5% (n = 2844) were men. The mean age was 46.9 years overall, 47.2 years in men and 46.6 in women (p = 0.071). In age, sex, race, education, marital status, adiposity, smoking, C-reactive protein adjusted linear regressions, antioxidant, serum α-carotene, trans-ß-carotene, cis- ß-carotene, ß-cryptoxanthin and combined Lutein/zeaxanthin were positively and significantly associated with TL (all p < 0.001).CONCLUSIONS:
Our findings support a possible positive association between serum concentrations of lipophylic antioxidant and TL. The implications of this association deserve further investigation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Telomere
/
Leukocytes
/
Antioxidants
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
Lipids Health Dis
Journal subject:
BIOQUIMICA
/
METABOLISMO
Year:
2018
Document type:
Article
Affiliation country:
Sweden