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High Affinity Neutral Bodipy Fluorophores for Mitochondrial Tracking.
Gayathri, Thumuganti; Karnewar, Santosh; Kotamraju, Srigiridhar; Singh, Surya Prakash.
Affiliation
  • Gayathri T; Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology (IICT), Uppal Road, Tarnaka, Hyderabad 500007, India.
  • Karnewar S; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201 002, India.
  • Kotamraju S; Department of Applied Biology, CSIR- Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Singh SP; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201 002, India.
ACS Med Chem Lett ; 9(7): 618-622, 2018 Jul 12.
Article in En | MEDLINE | ID: mdl-30034589
ABSTRACT
We report the first high affinity neutral Bodipy fluorophores for selective imaging of mitochondria with notable sensitivity (∼100 nM) and insignificant cytotoxicity even at very high concentration (∼100 µM), when tested against HeLa cells. Further, these fluorophores are chemically robust and require no special conditions for storage.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2018 Document type: Article Affiliation country: India
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: ACS Med Chem Lett Year: 2018 Document type: Article Affiliation country: India