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The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats.
Pentel, Paul R; Raleigh, Michael D; LeSage, Mark G; Thisted, Thomas; Horrigan, Stephen; Biesova, Zuzana; Kalnik, Matthew W.
Affiliation
  • Pentel PR; University of Minnesota, 100 Church St. S.E, Minneapolis, MN, 55455, USA.
  • Raleigh MD; Minneapolis Medical Research Foundation, 701 Park Ave, Minneapolis, MN, 55415, USA. rale0011@umn.edu.
  • LeSage MG; Minneapolis Medical Research Foundation, 701 Park Ave, Minneapolis, MN, 55415, USA.
  • Thisted T; Antidote Therapeutics Inc, 708 Quince Orchard Road, Suite 250-C, Gaithersburg, MD, 20878, USA.
  • Horrigan S; Noble Life Sciences, PO Box 242, Woodbine, MD, 21797, USA.
  • Biesova Z; Antidote Therapeutics Inc, 708 Quince Orchard Road, Suite 250-C, Gaithersburg, MD, 20878, USA.
  • Kalnik MW; Antidote Therapeutics Inc, 708 Quince Orchard Road, Suite 250-C, Gaithersburg, MD, 20878, USA.
BMC Biotechnol ; 18(1): 46, 2018 07 24.
Article in En | MEDLINE | ID: mdl-30041697
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monoamine Oxidase / Nicotine Type of study: Prognostic_studies Limits: Animals Language: En Journal: BMC Biotechnol Journal subject: BIOTECNOLOGIA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monoamine Oxidase / Nicotine Type of study: Prognostic_studies Limits: Animals Language: En Journal: BMC Biotechnol Journal subject: BIOTECNOLOGIA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United kingdom