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IgA regulates the composition and metabolic function of gut microbiota by promoting symbiosis between bacteria.
Nakajima, Akira; Vogelzang, Alexis; Maruya, Mikako; Miyajima, Michio; Murata, Megumi; Son, Aoi; Kuwahara, Tomomi; Tsuruyama, Tatsuaki; Yamada, Satoshi; Matsuura, Minoru; Nakase, Hiroshi; Peterson, Daniel A; Fagarasan, Sidonia; Suzuki, Keiichiro.
Affiliation
  • Nakajima A; Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Vogelzang A; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
  • Maruya M; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
  • Miyajima M; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
  • Murata M; Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Son A; Center for Innovation in Immunoregulative Technology and Therapeutics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Kuwahara T; Department of Microbiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
  • Tsuruyama T; Center for Anatomical, Pathological, Forensic Medical Research and Department of Drug and Discovery Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Yamada S; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Matsuura M; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Nakase H; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Peterson DA; Department of Gastroenterology and Hepatology, School of Medicine, Sapporo Medical University, Sapporo, Japan.
  • Fagarasan S; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Suzuki K; Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN Yokohama Institute, Yokohama, Japan.
J Exp Med ; 215(8): 2019-2034, 2018 08 06.
Article in En | MEDLINE | ID: mdl-30042191
ABSTRACT
Immunoglobulin A (IgA) promotes health by regulating the composition and function of gut microbiota, but the molecular requirements for such homeostatic IgA function remain unknown. We found that a heavily glycosylated monoclonal IgA recognizing ovalbumin coats Bacteroides thetaiotaomicron (B. theta), a prominent gut symbiont of the phylum Bacteroidetes. In vivo, IgA alters the expression of polysaccharide utilization loci (PUL), including a functionally uncharacterized molecular family provisionally named Mucus-Associated Functional Factor (MAFF). In both mice and humans, MAFF is detected predominantly in mucus-resident bacteria, and its expression requires the presence of complex microbiota. Expression of the MAFF system facilitates symbiosis with other members of the phylum Firmicutes and promotes protection from a chemically induced model of colitis. Our data reveal a novel mechanism by which IgA promotes symbiosis and colonic homeostasis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Symbiosis / Bacteria / Immunoglobulin A / Gastrointestinal Microbiome Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Exp Med Year: 2018 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Symbiosis / Bacteria / Immunoglobulin A / Gastrointestinal Microbiome Type of study: Prognostic_studies Limits: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Exp Med Year: 2018 Document type: Article Affiliation country: Japan