Arterial pH and blood gas values in rats under three types of general anesthesia: a chronobiological study.
Physiol Res
; 67(5): 721-728, 2018 11 14.
Article
in En
| MEDLINE
| ID: mdl-30044117
ABSTRACT
The aim of study was to review the status of arterial pH, pO(2) and pCO(2) under general anesthesias in dependence on the light-dark (LD) cycle in spontaneously breathing rats. The experiments were performed using three- to four-month-old pentobarbital(P)-, ketamine/xylazine(K/X)- and zoletil(Z)-anesthetized female Wistar rats after a four-week adaptation to an LD cycle (12 h light12 h dark). The animals were divided into three experimental groups according to the anesthetic agent used P (light n=11; dark n=8); K/X (light n=13; dark n=11); and Z (light n=18; dark n=26). pH and blood gases from arterial blood were analyzed. In P anesthesia, LD differences in pH, pO(2), and pCO(2) were eliminated. In K/X anesthesia, parameters showed significant LD differences. In Z anesthesia, LD differences were detected for pH and pO(2) only. Acidosis, hypoxia, and hypercapnia have been reported for all types of anesthesia during the light period. In the dark period, except for P anesthesia, the environment was more stable and values fluctuated within normal ranges. From a chronobiological perspective, P anesthesia was not the most appropriate type of anesthesia in these rat experiments. It eliminated LD differences, and also produced a more acidic environment and more pronounced hypercapnia than K/X and Z anesthesias.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pentobarbital
/
Tiletamine
/
Zolazepam
/
Chronobiology Phenomena
/
Anesthetics, General
/
Anesthesia, General
/
Ketamine
Limits:
Animals
Language:
En
Journal:
Physiol Res
Journal subject:
FISIOLOGIA
Year:
2018
Document type:
Article