Two new inflammatory markers associated with disease activity score-28 in patients with rheumatoid arthritis: Albumin to fibrinogen ratio and C-reactive protein to albumin ratio.
Int Immunopharmacol
; 62: 293-298, 2018 Sep.
Article
in En
| MEDLINE
| ID: mdl-30048859
ABSTRACT
BACKGROUND:
The albumin to fibrinogen ratio (AFR) and C-reactive protein to albumin ratio (CAR) have emerged as useful biomarkers to predict systemic inflammation. The aim here is to investigate the relation between AFR/CAR and Disease Activity Score of 28 joints (DAS 28) in rheumatoid arthritis (RA).METHODS:
This retrospective study included 160 patients with RA and 159 healthy controls. We divided the RA patients into two groups according to the DAS 28-ESR score. Group 1 included 40 patients with a score of lower than 2.6 (patients in remission) and Group 2 included 120 patients with a score of 2.6 or higher (patients with active disease). The correlations between AFR, CAR and the disease activity were analyzed.RESULTS:
For RA patients, the AFR was lower than those in the control group (Pâ¯<â¯0.001). Patients in group 2 had higher CAR than those in group 1 (Pâ¯<â¯0.001). The AFR was lower in group 2 than that in group 1. A positively correlation was observed between DAS 28-ESR score and CAR (râ¯=â¯0.645, Pâ¯<â¯0.001), while the correlation between DAS 28-ESR and AFR (râ¯=â¯-0.836, Pâ¯<â¯0.001) was negative. AFR was related with decreased risk of RA disease activity (EXP (B)â¯=â¯0.33, 95% CI (0.21-0.53), Pâ¯<â¯0.001).CONCLUSIONS:
AFR and CAR are two novel inflammatory markers for monitoring disease activity in patients with RA.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Rheumatoid
/
Severity of Illness Index
/
C-Reactive Protein
/
Fibrinogen
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Serum Albumin
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int Immunopharmacol
Journal subject:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
Year:
2018
Document type:
Article
Affiliation country:
China