Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture.

Timm, Sara; Lorat, Yvonne; Jakob, Burkhard; Taucher-Scholz, Gisela; Rübe, Claudia E

Timm, Sara; Lorat, Yvonne; Jakob, Burkhard; Taucher-Scholz, Gisela; Rübe, Claudia E.

Affiliation

Timm S; Department of Radiation Oncology, Saarland University, Homburg/Saar, Germany.
Lorat Y; Department of Radiation Oncology, Saarland University, Homburg/Saar, Germany.
Jakob B; Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany.
Taucher-Scholz G; Department of Biophysics, GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany.
Rübe CE; Department of Radiation Oncology, Saarland University, Homburg/Saar, Germany. Electronic address: claudia.ruebe@uks.eu.

Radiother Oncol ; 129(3): 600-610, 2018 12.

Article in En | MEDLINE | ID: mdl-30049456

Subject(s)

Chromatin/radiation effects; DNA Damage; Animals; Cells, Cultured; Chromatin/ultrastructure; DNA Breaks, Double-Stranded; DNA Repair; Humans; Ku Autoantigen/analysis; Linear Energy Transfer; Tumor Suppressor p53-Binding Protein 1/analysis

Key words

Charged-particle radiotherapy; Chromatin remodeling; DNA damage; Double-strand breaks (DSBs); Non-homologous end joining (NHEJ); Particle trajectories; Transmission electron microscopy (TEM)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Chromatin Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Radiother Oncol Year: 2018 Document type: Article Affiliation country: Germany

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