The phosphoinositide-3 kinase (PI3K)-Î´,Î³ inhibitor, duvelisib shows preclinical synergy with multiple targeted therapies in hematologic malignancies.

Faia, Kerrie; White, Kerry; Murphy, Erin; Proctor, Jennifer; Pink, Melissa; Kosmider, Nicole; McGovern, Karen; Kutok, Jeffery

Faia, Kerrie; White, Kerry; Murphy, Erin; Proctor, Jennifer; Pink, Melissa; Kosmider, Nicole; McGovern, Karen; Kutok, Jeffery.

Affiliation

Faia K; Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America.
White K; Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America.
Murphy E; Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America.
Proctor J; Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America.
Pink M; Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America.
Kosmider N; Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America.
McGovern K; Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America.
Kutok J; Infinity Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America.

PLoS One ; 13(8): e0200725, 2018.

Article in En | MEDLINE | ID: mdl-30067771

Subject(s)

Hematologic Neoplasms/drug therapy; Isoquinolines/therapeutic use; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors/therapeutic use; Purines/therapeutic use; Animals; Apoptosis/drug effects; Bridged Bicyclo Compounds, Heterocyclic/pharmacology; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use; Cell Line, Tumor; Drug Synergism; Everolimus/pharmacology; Everolimus/therapeutic use; Female; Humans; Isoquinolines/pharmacology; Mice; Mice, SCID; NF-kappa B/antagonists & inhibitors; NF-kappa B/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Protein Kinase Inhibitors/pharmacology; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/metabolism; Purines/pharmacology; Sulfonamides/pharmacology; Sulfonamides/therapeutic use; TOR Serine-Threonine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/metabolism; Transplantation, Heterologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Hematologic Neoplasms / Protein Kinase Inhibitors / Phosphoinositide-3 Kinase Inhibitors / Isoquinolines Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United States

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