The mycosporine-like amino acids porphyra-334 and shinorine are antioxidants and direct antagonists of Keap1-Nrf2 binding.

Gacesa, Ranko; Lawrence, Karl P; Georgakopoulos, Nikolaos D; Yabe, Kazuo; Dunlap, Walter C; Barlow, David J; Wells, Geoffrey; Young, Antony R; Long, Paul F

Gacesa, Ranko; Lawrence, Karl P; Georgakopoulos, Nikolaos D; Yabe, Kazuo; Dunlap, Walter C; Barlow, David J; Wells, Geoffrey; Young, Antony R; Long, Paul F.

Affiliation

Gacesa R; Faculty of Life Sciences & Medicine, King's College London, United Kingdom.
Lawrence KP; Faculty of Life Sciences & Medicine, King's College London, United Kingdom.
Georgakopoulos ND; School of Pharmacy, University College London, United Kingdom.
Yabe K; Chemical Laboratory, Hokkaido University of Education, Japan.
Dunlap WC; Faculty of Life Sciences & Medicine, King's College London, United Kingdom.
Barlow DJ; Faculty of Life Sciences & Medicine, King's College London, United Kingdom.
Wells G; School of Pharmacy, University College London, United Kingdom.
Young AR; Faculty of Life Sciences & Medicine, King's College London, United Kingdom.
Long PF; Faculty of Life Sciences & Medicine, King's College London, United Kingdom. Electronic address: paul.long@kcl.ac.uk.

Biochimie ; 154: 35-44, 2018 Nov.

Article in En | MEDLINE | ID: mdl-30071261

Subject(s)

Antioxidants; Cyclohexanones; Cyclohexylamines; Fibroblasts/metabolism; Gene Expression Regulation/drug effects; Glycine/analogs & derivatives; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Antioxidants/chemistry; Antioxidants/pharmacology; Cyclohexanones/chemistry; Cyclohexanones/pharmacology; Cyclohexylamines/chemistry; Cyclohexylamines/pharmacology; Fibroblasts/cytology; Glycine/chemistry; Glycine/pharmacology; Humans; Kelch-Like ECH-Associated Protein 1/antagonists & inhibitors; Kelch-Like ECH-Associated Protein 1/chemistry; Kelch-Like ECH-Associated Protein 1/metabolism; NF-E2-Related Factor 2/antagonists & inhibitors; NF-E2-Related Factor 2/chemistry; NF-E2-Related Factor 2/metabolism

Key words

Antioxidants; Mycosporine-like amino acids; Natural products; Nrf2; Oxidative stress

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation / Cyclohexanones / Cyclohexylamines / NF-E2-Related Factor 2 / Fibroblasts / Kelch-Like ECH-Associated Protein 1 / Glycine / Antioxidants Limits: Humans Language: En Journal: Biochimie Year: 2018 Document type: Article Affiliation country: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google