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Characterization of New Polyphenolic Glycosidic Constituents and Evaluation of Cytotoxicity on a Macrophage Cell Line and Allelopathic Activities of Oryza sativa.
Chung, Ill-Min; Kwon, Chang; An, Yeonju; Ali, Mohd; Lee, Hannah; Lim, Jung-Dae; Kim, Soyeon; Yang, Yujin; Kim, Seung-Hyun; Ahmad, Ateeque.
Affiliation
  • Chung IM; Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. imcim@konkuk.ac.kr.
  • Kwon C; Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. chang794@konkuk.ac.kr.
  • An Y; Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. ayj3043@konkuk.ac.kr.
  • Ali M; Department of Pharmacognosy and Phytochemistry, Hamdard University, New Delhi 110062, India. maliphyto@gmail.com.
  • Lee H; Department of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Korea. dlgkssk1009@naver.com.
  • Lim JD; Department of Herbal Medicine Resource, Kangwon National University, Samcheok 25949, Korea. ijdae@kangwon.ac.kr.
  • Kim S; Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. hellosy1@konkuk.ac.kr.
  • Yang Y; Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. jin9031@konkuk.ac.kr.
  • Kim SH; Department of Applied Bioscience, College of Life and Environmental Science, Konkuk University, Seoul 05029, Korea. kshkim@konkuk.ac.kr.
  • Ahmad A; Process Chemistry and Technology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India. ateeque97@gmail.com.
Molecules ; 23(8)2018 Aug 02.
Article in En | MEDLINE | ID: mdl-30072644
ABSTRACT
Four new constituents, as 5, 7-dihydroxy-4'-methoxyflavonol-3-O-ß-d-arabinopyranosyl-(2''→1''')-O-ß-d-arabinopyrnosyl-2'''-O-3'''', 7''''-dimethylnonan-1''''-oate (1), 5-hydroxy-7, 4'-dimethoxyflavone-5-O-α-d-arabinopyranosyl-(2"→1''')-O-α-d-arabinopyranosyl-2'''-O-3'''', 7''''-dimethylnonan-1''''-oate (2), 5-hydroxy-7, 4'-dimethoxyflavone-5-O-ß-d-arabinofuranosyl-(2"→1''')-O-ß-d-arabinopyranosyl-2'''-O-lanost-5-ene (3) and 4',4''-diferuloxy feruloyl-O-α-d-arabinopyranosyl-(2a→1b)-O-α-d-arabinopyranosyl-(2b→1c)-O-α-d-arabinopyranosyl-(2c→1d)-O-α-d-arabinopyranosyl-(2d→1e)-O-α-d-arabinopyranosyl-2e-3''', 7'''-dimethylnonan-1'''-oate (4), along with three known compounds (5⁻7) were isolated from Oryza sativa leaves and straw. The structures of new and known compounds were elucidated by 1D (¹H and 13C NMR) and 2D NMR spectral methods, viz COSY, HMBC, and HSQC aided by mass techniques and IR spectroscopy. The cytotoxicity of these constituents was assessed by using (RAW 264.7) mouse macrophage cell line, and allelopathic effects of compounds (1⁻7) on the germination and seedling growth characteristics such as seedling length and root length of barnyardgrass (Echinochloa oryzicola) were evaluated. Significant inhibitory activity was exhibited by compounds comprising flavone derivatives such as (1⁻3) on all of seed germination characteristics. The allelopathic effect of flavone derivatives were more pronounced on seedling length and root length than the germination characteristics. The higher concentration of flavone derivatives showed stronger inhibitory effects, whereas the lower concentrations showed stimulatory effects in some cases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pheromones / Oryza / Polyphenols / Glycosides / Macrophages Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2018 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pheromones / Oryza / Polyphenols / Glycosides / Macrophages Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2018 Document type: Article
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