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Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists.
Amato, George S; Manke, Amruta; Vasukuttan, Vineetha; Wiethe, Robert W; Snyder, Rodney W; Runyon, Scott P; Maitra, Rangan.
Affiliation
  • Amato GS; Discovery Science and Technology, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
  • Manke A; Discovery Science and Technology, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
  • Vasukuttan V; Discovery Science and Technology, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
  • Wiethe RW; Discovery Science and Technology, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
  • Snyder RW; Discovery Science and Technology, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
  • Runyon SP; Discovery Science and Technology, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA.
  • Maitra R; Discovery Science and Technology, RTI International, 3040 Cornwallis Rd., Research Triangle Park, NC 27709-2194, USA. Electronic address: rmaitra@rti.org.
Bioorg Med Chem ; 26(15): 4518-4531, 2018 08 15.
Article in En | MEDLINE | ID: mdl-30077609
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Receptor, Cannabinoid, CB1 Limits: Animals / Female / Humans / Male Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Purines / Receptor, Cannabinoid, CB1 Limits: Animals / Female / Humans / Male Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Affiliation country: United States Country of publication: United kingdom